My kids were both pretty girly and comfortable in their own skins when they were little, if at age 12 they'd out of the blue told me they wanted puberty blockers it'd have been wildly out of character. So yes - side effects or no I would have been very wary. If they'd always wanted to be boys that'd be a different story I guess, but ... well, these are real people, not abstract ideas, it's hard to imagine them being different to how they areI highly doubt you'd want your kids to take blockers even if they had no side effects - would you?
Yes or No?
So it isn't solely based on that.